Deb, L. and Dey, A. and Sakthivel, G. (2013) Protective effect of Clerodendrum colebrookianum Walp., on acute and chronic inflammation in rats. Indian Journal Of Pharmacology, 45 (4). pp. 376-380.

Full text not available from this repository.

Abstract

"Aim: To evaluate antioxidant, anti-inflammatory potential of the aqueous extracts and its aqueous, n-butanol, ethyl-acetate, and chloroform fractions of Clerodendrum colebrookianum Walp. leaves. Materials and Methods: In this present study, all the test samples were evaluated on in-vivo inflammatory model such as carrageenan and histamine-induced acute-inflammation and cotton pellet induced granuloma formation in albino male rats. Test samples were also employed in in-vitro assays like DPPH* free radical scavenging activity and COX inhibition assay. Results: The test samples at the dose of 200mg/kg/p.o. were found to cause significant inhibition of carrageenan and histamine-induced inflammation and cotton pallet-induced granuloma formation on acute and chronic inflammation in rats. The test samples, except n-butanol fraction, exhibited inhibitory effect for both COX-1 and COX-2, in in-vitro assay but their percentage of inhibition values differs from each other. The test samples (aqueous extracts, aqueous, n-butanol, ethyl-acetate, and chloroform fractions) at 100 mu g concentration exhibits 54.37%, 33.88%, 62.85%, 56.28%, and 57.48% DPPH* radical-scavenging effect respectively in in-vitro antioxidant study. Conclusion: These observations established the anti-inflammatory effect of C. colebrookianum leaves in acute and chronic stages of inflammation by free radical scavenging and inhibition of COX-1 and COX-2."

Item Type:	Article
Subjects:	Plant Bioresources
Depositing User:	Unnamed user with email alok@urdip.res.in
Date Deposited:	09 Apr 2015 04:54
Last Modified:	09 Apr 2015 04:54
URI:	http://ibsd.sciencecentral.in/id/eprint/9

Actions (login required)

View Item