Sakthivel, G. and Dey, A. and Nongalleima, K. and Chavali, M. In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell's Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies. Evidence-based complementary and alternative medicine, 2013. p. 781216.

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Abstract

The present study emphasizes to reveal the antivenom activity of Aristolochia bracteolata Lam., Tylophora indica (Burm.f.) Merrill, and Leucas aspera S. which were evaluated against venoms of Daboia russelli russelli (Russell's viper) and Naja naja (Indian cobra). The aqueous extracts of leaves and roots of the above-mentioned plants and their polyherbal (1:1:1) formulation at a dose of 200mg/kg showed protection against envenomed mice with LD50 doses of 0.44mg/kg and 0.28mg/kg against Russell's viper and cobra venom, respectively. In in vitro antioxidant activities sample extracts showed free radical scavenging effects in dose dependent manner. Computational drug design and docking studies were carried out to predict the neutralizing principles of type I phospholipase A2 (PLA2) from Indian common krait venom. This confirmed that aristolochic acid and leucasin can neutralize type I PLA2 enzyme. Results suggest that these plants could serve as a source of natural antioxidants and common antidote for snake bite. However, further studies are needed to identify the lead molecule responsible for antidote activity.

Item Type:	Article
Subjects:	Plant Bioresources
Depositing User:	Unnamed user with email alok@urdip.res.in
Date Deposited:	09 Apr 2015 05:03
Last Modified:	09 Apr 2015 05:03
URI:	http://ibsd.sciencecentral.in/id/eprint/11

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